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Senescent cells are characterized by an irreversible G 1 growth arrest involving the repression of genes that drive cell cycle progression and the upregulation of cell cycle inhibitors like p16 INK4a , p53, and its transcriptional target, p21 CIP1

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doi: 10.1016/j.molmet.2023.101755 5 AntonelliMKushnerI

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In basic environments, it undergoes hydrolytic degradation and alpha, beta-unsaturated beta-diketone moiety cleavage ( Reports have shown that 90% of curcumin degradation under alkaline and neutral conditions occurred within 1530 min, while in acidic incubations, degradation was substantially slower, with less than 20% of total curcumin degraded within 60 min ( 9.2 Autooxidation of curcumin Curcumin is also susceptible to autooxidation, which occurs through radical chain reactions and spontaneously occurs in aqueous solutions (187)

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