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However, under certain circumstances such as during an Autoimmune response, neutrophils can be triggered to release ROS extracellularly causing damage to host tissues, modification of host proteins, lipids and DNA and dysregulation of oxidative homeostasis

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[PubMed] [Elsevier] Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP (May 2007)

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Temperature stress High temperature in plants enhances the generation of ROS, consequently inducing oxidative stress (Yin et al., 2008)