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Impairment of glymphatic clearance is associated with A plaque deposition in APP-PS1 mice Two-photon imaging revealed fibrillar amyloid plaques in the parenchyma, but no evidence of CAA in 78-month-old APP-PS1 mice (Fig

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393 Other novel targets P2Y14R, a member of the purinergic receptor family, has been shown to promote the transcription of RIPK1 through the cAMP/PKA/CREB signaling axis, thereby driving necrotic apoptosis of intestinal epithelial cells and exacerbating intestinal barrier disruption and inflammatory responses