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Lunardi C, Bason C, Leandri M, et al

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1 Introduction Colorectal cancer (CRC) remains a major global health burden, ranking as the third most frequently diagnosed cancer and the second leading cause of cancer-related mortality worldwide ( de novo anti-tumor immune response

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Research indicated that the tumor-associated bacteria in PDAC were moved from the gut to the pancreatic duct, and the microenvironment of this adenocarcinoma may enhance sensitivity to bacterial translocation (Leinwand and Miller, 2020)

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