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Contrary to the aforementioned editorial claims, BTIs are often associated with worse outcomes, including severe or critical illness in ~11% of cases, linked to comorbidities like cardiovascular disease, and mortality rates around 0.9%substantially higher than the 0.03-0.05% infection fatality rate for natural SARS-CoV-2 infections in similar populations

[3] In regional anesthesia, the recommended maximum single dose without epinephrine is 4.5 mg/kg (not to exceed 300 mg)

Adjuncts : In cases of unwanted estrogen-related effects (water retention, mood changes, gynecomastia), pairing with an aromatase inhibitor can be considered

It is not a stabilized peptide but a small molecule ERR receptor agonist, designed from the start for the oral route

cstc2021jcyj-msxmX0306)

doi: 10.1182/blood-2017-06-740944