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Description

Mechanistically, phenylacetylglutamine has been shown to induce mitochondrial stress and elevate ROS levels, leading to cellular senescence and tissue dysfunction (Yang et al., 2025)

In the future, rather than look for additional global markers of astrogliosis, it will likely be more useful to look for molecules upregulated by astrocytes in specific contexts and that are associated with specific functions or effects of astrogliosis