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4 Gut microbiota-derived metabolites and depression Bacterial compounds found in the gut can enter the bloodstream affect brain regions and can interact with nearby gut components like hormonal cells or neurons, which can subsequently send signals to the brain (161)

It also decreased the levels of c-Jun and c-Fos genes, luciferase activity of activator protein-1 (AP-1), IL-1-induced phosphorylation of JNK (c-Jun N-terminal kinase), and consequently reduced the JNK/AP-1 signaling

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Kennedy, who has said he used peptides with "really good effect," has argued that restrictions on the compounds have pushed consumers toward an unregulated grey market