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Therefore, anatomic ablation has been adopted worldwide

Earlier recommendations advocated treatment of the cobalamin C defect with a combined approach that utilizes vitamin B12 plus betaine to provide a substrate for the conversion of homocysteine into methionine through betaine-homocysteine methyltransferase, and folic acid to enhance the remethylation pathway (164)

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The prevalence of its reduced form in cells is due to the activity of glutathione reductase, which is both constitutive and inducible in response to oxidative stress