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Additionally, CKD can develop into end-stage kidney disease (ESKD), which necessitates renal replacement therapy in addition to dialysis and/or kidney transplantation for patients

Because IDO1 -associated inflammatory activation would be expected to increase, rather than decrease, the Kyn/Trp ratio [46,47,48], a one-tailed analysis was also performed

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Methods Pregnant SpragueDawley (SD) rats were obtained at day 11 of gestation and allowed to acclimate for 7 days before initiating the experiments (Fig