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However, it is important to note that while the high energy demand theory is widely accepted, in vivo evidence directly confirming it as the primary or sole cause of neuronal loss in PD remains incomplete, as other factors such as calcium dyshomeostasis and iron metabolism abnormalities are also intertwined [20, 21]

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In contrast, the fluorescent BEAGA/ApoE-PDHD first accumulated on the wall of brain microvessels and then gradually permeated into brain parenchyma along with the increase in post-injection time

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She started in pharmaceutical research, spent nearly a decade contributing to clinical trials, then traded the lab for the front lines, serving in the North Dakota Army National Guard and deploying to Afghanistan

Author contributions XL wrote the manuscript