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Nanoscale 13 , 163174 (2021)

At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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Therefore, it is often assumed that Planaria must have a high genomic stability and/or efficient DNA repair mechanisms (Sahu et al., 2017