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doi:10.1016/j.mce.2013.06.014 Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T (2003) A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

The newly generated pyruvate later crosses the mitochondrial inner membrane in favor of presumptive pyruvate transporters MPC (MPC1 and MPC2) and/or MCT1 (16, 49), to transform into acetyl-CoA for entering the tricarboxylic acid cycle (TCA) and therefore producing 1417 ATPs per lactate molecule for maintaining neuronal activity (26)

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The dual HPLC and mass-spec approach is the correct standard, since purity and identity are separate questions and a compound can be pure yet incorrectly identified