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Interestingly, Ruminocaccaceae family, have been associated with the organic metabolite Trimethylamine N-oxide (TMAO) levels, playing an important role in the development of atherosclerosis and increased cardiovascular risk 127 ,while Bifidobacteriaceae or Streptococcaceae influence on glucose and fat metabolism 126

Mucous membrane involvement: Loss of colour may affect the tissues lining the inside of the mouth and nose

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GHK-Cu is an endogenous occurring copper-binding tripeptide composed of glycine (G), histidine (H), and lysine (K)

NF-B then upregulates VEGF and pro-inflammatory cytokines such as TNF- and IL-6, further driving angiogenesis [70]