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7883 Discussion There has been no in vitro or in vivo research that specifically examines the effect of N-acetylcysteine on COVID-19 infection

Some previous studies supported our results

10.1016/S0020-7292(01)00494-5 121 NikooS.EbtekarM.Jeddi-TehraniM.ShervinA.BozorgmehrM.KazemnejadS.et al (2012)

Masayuki Yamamotos lab identified halofuginone in a chemical library screen and demonstrated effective NRF2 suppression via suppression of prolyl-tRNA synthetase activity and amino acid starvation response [89]

Ranade et al., 2014

In particular, the 55 most highly expressed genes in the invasive MC58 strain included genes encoding proteins involved in amino acid transport and metabolism ( argH , aroA , aroB , ilvC , and gdhA ), genes for ATP synthase subunits ( atpA , atpD , atpG ), genes involved in sialic acid capsule biosynthesis ( siaB , siaC ), and an operon encoding Na + -translocating NADH-quinone reductase subunits ( nqrB , nqrC , nqrD )