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Therefore, noting the lack of spontaneous oxidation of free GSH between the two EDTA-treated samples stored at 80 o C, this result also suggests that the differences in GSH between the heparinized plasma (Preparation Condition 1) and deproteinized EDTA-treated plasma (Preparation Condition 2) are due to spontaneous oxidation of free GSH occurring in the heparinized plasma prior to the deproteinization process

The calcium chelator BAPTA-AM blocked both TFG translocation and CHMP4BmNG accumulation on damaged lysosomes, when co-administered with LLOMe (Fig

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This paves the way for developing precision anti-inflammatory therapies and, coupled with advanced delivery systems like nanocarriers for targeted brain delivery, holds significant potential for providing causative treatment for tinnitus patients identified as belonging to an inflammatory subtype based on their specific biomolecular profile (He S

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10.1152/ajpcell.00643.2008 Am