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individuals with a personal history of cancer should discuss this explicitly with their specialist before use [8] [9] Retatrutide's side effect profile, based on published Phase 2 trial data (with Phase 3 trials ongoing), includes: Nausea, vomiting, and diarrhoea particularly during dose escalation Reduced appetite , which may lead to nutritional deficiencies if not monitored Increased heart rate Gallbladder-related complications , including cholelithiasis, consistent with the GLP-1 receptor agonist class When used together, these risks may compound