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Osteoarthritis has long been perceived as an inevitable consequence of age or joint wear and tear

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[11] In clinical research settings and certain intensive protocols (such as addiction detoxification), much higher NAD+ dosages have been utilized

[1] [2] These include reduced caloric intake due to appetite suppression, gastrointestinal side effects leading to decreased food intake, delayed gastric emptying, changes in blood glucose levels, and the metabolic adjustments associated with significant weight loss

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