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The field of the invention relates generally to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof, and the uses thereof

In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo

The cation of 7 is NH 2

doi: 10.1111/bjh.15433 80 MalavasiFDeaglioSDamleRCutronaGFerrariniMChiorazziN

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