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Dierckx, B., Heijnen, W

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Discovery of (R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a novel orally bioavailable EAAT2 modulator with drug-like properties and potent antiseizure activityin vivo

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Huang R, Wang P, Han J, Xia W, Cai R, Sun H, et al

71 , 72 During the acute action of MDMA, SPECT studies show a downregulation of serotonin receptors (an adaptive response to the increased release of serotonin) in the cerebral cortex, 73 but in long-term users in the drug-free state there is upregulation of receptors (an adaptive response to the decrease in serotonin release)