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These include genes related to the modulation of reactive oxygen species (ROS), such as voltage-gated proton channel genes (two upregulated, three downregulated) and cytochrome b5 reductase genes (two upregulated)

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M., Brambilla, E., Faivre-Finn, C

For instance, in AD mice, mitochondrial damage increases mtDNA leakage into the cytosol, where it engages cGAS and activates STING, driving microglial secretion of type I interferons and pro-inflammatory cytokines that contribute to neuronal dysfunction [93]

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