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Although, autoantibodies against serotonin have been associated with ME/CFS (506, 508)

doi: 10.1016/bs.afnr.2017.11.003

The liver changes most tryptophan into nicotinamide before releasing it into the blood for other tissues to use

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For example, in 2018, Fava et al authored an extensive review of 22 double-blind randomized controlled trials, numerous open trials, and 23 case reports on various types of second-generation antidepressants like Cymbalta