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451 In postmortem brain specimens, there were no transcription differences between MDD men and controls, and the levels of 5-HT 1D receptors and the transcription factors NUDR and REST, which regulate 5-HT activity, in 5-HT-containing neurons in the ventral raphe nuclei were found to be higher in MDD females

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The formation of TLS was significantly inhibited in the kidneys of sulfasalazine-treated mice (Supplemental Figure 9, BD)

While this impairment in immune function is a mechanism of increased tumor burden in patients with obesity, it is effectively reduced by immunotherapy treatments and indicative of ICI response in several cancer types [38]