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Cosson, C

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Outside-In Because CNS pathology, especially that of white matter, so often involves damage to both myelin, glia, and axons, universally accompanied by an immune response, it is extremely difficultbut at the same time very importantto disentangle the precise sequence of events that trigger MS

some conclusions on platinum accumulation and long-term complications are only based on observational cohort data, with unadjusted confounding factors, leaving the causal evidence chain to be further improved

Princiotta MF, Finzi D, Qian SB, Gibbs J, Schuchmann S, Buttgereit F, et al