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doi: 10.1016/j.xcrm.2023.101254 80 ShahbazSBozorgmehrNLuJOsmanMSliglWTyrrellDLet al

Overcoming these barriers requires multidisciplinary collaboration: leveraging medicinal chemistry to optimize drug-like properties, utilizing toxicology to define safety margins, and applying systems biology to guide the design of precision clinical trials

Disrupted NAD+/NADH levels and ratio Nicotinamide adenine dinucleotide (NAD) is an electron acceptor during oxidative phosphorylation catalyzed by mitochondrial electron transport chain (ETC)