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It helps balance injection volume convenience against measurement precision, outputting concentration for any given reconstitution

doi:10.1002/mds.27228

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increasing the dose did not yield proportional gains, underscoring the importance of optimisation rather than maximisation [182]

however, the specific interactions between these mechanisms remain nebulous, and existing models cannot fully explain the presence of diabetic neuropathic pain

For example, at the molecular level, the rhythmic response and toxicity of 5-FU are dependent upon circadian oscillations in thymidylate synthase activity, its molecular target, and dihydropyrimidine dehydrogenase activity (DPD), the rate-limiting enzyme responsible for its elimination 102,103