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Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide

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Analyses described above for the main analysis were repeated, stratified by patterns of EFV and TDF use before and after switch to DOR: (a) TDF and/or EFV before & TDF after, (b) no TDF or EFV before & after, (c) TDF and/or EFV before only, and (d) TDF after only