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Description

Exercise training activates the PI3K-akt pathway in the heart

Cytosolic glutamate is critical for GSH synthesis, which in turn functions as reducing substrate for GPX4, an essential enzyme to protect the cell against oxidative damage (Figure 1A)

After dividing participants into two groups by sex, we found that only males showed a decrease of PRESS GSH levels in the ACC with age and a significant group difference in the relationship between GSH levels and age

(London England) 38 (1), 12 (2018)

Der genaue Prozess wird als Konjugation (Phase-II-Biotransformation) bezeichnet und beschreibt die Verknpfung von krpereigenen oder von auen aufgenommenen Stoffen mit Glutathion, um diese unschdlich zu machen und sie in der Folge weiter abzubauen oder auszuscheiden 1