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Among naturally occurred inhibitors, sesquiterpenoids with an ,-unsaturated lactone moiety have great potentials because they covalently bind to amino acid residues Cys46 and Cys179 of IKK

The dual role of reactive oxygen species-generating nicotinamide adenine dinucleotide phosphate oxidases in gastrointestinal inflammation and therapeutic perspectives

Resveratrol, quercetin, and apigenin have been reported to neutralize ROS and upregulate antioxidant enzymes like superoxide dismutase (SOD) and heme oxygenase1 (HO 1 ) in cellular PD models [39, 62]