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Lavrencak J

Modulation of pro-oxidant and pro-inflammatory activities of M1 macrophages by the natural dipeptide carnosine

These integrative structures promote homeostatic efforts by maintaining a dynamic subjective image of the state of the body and the surrounding environment (116)

Nutrition, Metabolism and Cardiovascular Diseases (2019) 29(2):2018

This upregulation will in turn up-regulate at the transcriptional level the expression of proinflammatory cytokines (IL-1, IL-6, IL-18, etc.), chemokines, adhesion molecules, Fas ligands33 which will activate the caspase cascades (apoptosis) and the ATP depletion from mitochondria (necrosis) leading to an autosustaining and autopotentiating oxidative loop

Ketogenic diets have well-documented therapeutic benefits for many chronic diseases including obesity, diabetes, non-alcoholic fatty liver disease, and epilepsy