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Sci , vol

You need to follow your doctors instructions carefully, such as dosage or duration of treatment

As expected, overexpression of WT GCLC or its desuccinylation-mimicking mutants (K38R, K126R, K326R or 3KR) in U2OS cells significantly enhanced the cellular GSH levels compared to empty vector control (NC) (Fig

Although there are promising novel therapeutic approaches, further research is needed to better understand the disease mechanisms, develop therapies that target difficult to reach tissues and create adjuvant therapies that address secondary cellular processes caused by the enzyme deficiency