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Description

10.1111/nmo.12736 117

KPV derives from a hormone that contributes to skin pigmentation

Hydroxocobalamin, which the body retains longer than cyanocobalamin, often allows less frequent dosing once levels stabilize

The antibody has one arm equipped with biparatopic sequences reacting with distinct epitopes of the CD38 molecule

The clinical phenotype suggests an important role for collagen III in either the synthesis or deposition of heterotypic fibrils containing largely collagen I, but remarkably, the precise mechanism of disease is still unknown