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Because of their dissolving nature, water soluble antioxidant can be easily eliminated from the body through urine whereas lipid-soluble antioxidants can stay over a long time in the body

Biomarkers 11:355369 Tailor P, Raman T, Garganta CL, Njalsson R, Carlsson K, Ristoff E, Carey HB (2005) Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid)

Physical therapy may also be recommended

The stratification into mechanistic subtypes, such as neuroinflammation-dominant, could be guided by biomarkers like specific cytokines (e.g., associations found between interleukin-6 and tinnitus intensity (Tanaka et al., 2024)) or by functional imaging with specific tracers

To further assess the stability of the results, a series of sensitivity analyses were conducted, including Cochrans Q test, MR-Egger regression, and leave-one-out analysis