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3.3 Targeting BCL-2 family proteins: innovative strategies for directly activating BAX/BAK in cancer treatment Apoptosis, the primary mechanism of cell death in cancer cells, is meticulously regulated by BCL-2 family proteins (Singh et al., 2019)

The detoxification against H 2 O 2 in mitochondria occurs mainly through the GSH redox system, including the glutathione peroxidases (Gpxs) and GSH reductases, as well as the presence of peroxiredoxins (Prxs