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The present invention also provides a method for shuffling a pool of polynucleotide sequences selected by affinity screening a library of polysomes displaying nascent peptides (including single-chain antibodies) for library members which bind to a predetermined receptor (e.g., a mammalian proteinaceous receptor such as, for example, a peptidergic hormone receptor, a cell surface receptor, an intracellular protein which binds to other protein(s) to form intracellular protein complexes such as hetero-dimers and the like) or epitope (e.g., an immobilized protein, glycoprotein, oligosaccharide, and the like)

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In fact, modulation of particle size combined with multilayer composite structural optimization enables efficient transdermal penetration and targeted drug delivery, markedly improving the efficacy and durability of skin disease therapy [70]

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Patients should schedule follow-up appointments once a year to sustain their results

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