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These coordinated responses promote TFEB nuclear translocation, enhance lysosomal and autophagic gene expression more effectively than rapamycin and attenuate phosphorylated tau, total tau and p62 accumulation, highlighting zincs therapeutic potential in restoring lysosomal proteolysis and autophagy 103,167

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Alternative minimally invasive approaches may be used in selected circumstances

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Although the same effects have not yet been verified in humans, a study in mice showed that extreme restriction of both carbohydrates and protein should be avoided because of potential development of fatty liver Non-alcoholic-Fatty Liver-Disease (NAFLD) or even worse, progression of the fatty liver to actual liver damage as is seen in Non-alcoholic Steatohepatitis (NASH)