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In addition, the combination of QUE and 5-FU had a better inhibitory effect on the migration ability and the expression of MMP2 and MMP9 in highly invasive MDA-MB-231 cells than 5-FU alone (40)

So, it is expected that a similar set and quantity of phytoestrogens can induce dichotomic effects depending on the individuals idiosyncrasy

A polygenic risk score is a statistical estimate of an individuals genetic risk to a specific medical condition by combining the effects of multiple genetic variants