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10.7759/cureus.27666 28 CarolaC.SalazarA.RakersC.HimbertF.DoQ.-T.BernardP.et al (2021)

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Key Highlights 9.2.1.1

fibrillar aggregation The structure of S suggests that transient Smembrane interactions could be stabilized biochemically by either amplifying the electrostatic interaction between positive lysines in S and negative lipid head groups (e.g., via the engineered 3K S mutant) or by increasing the hydrophobicity in the lower, membrane-inserted half of the S amphipathic helix (e.g., via the engineered KLK S mutant) (Fig