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The bioenergetic pathway is also upregulated by treatment with OH Py 2 N 2 as evidenced by increased levels of ATP

Autophagic degradation of ferritin in cytoplasm or lysosome, known as ferritinophagy, could lead to elevated intracellular iron levels, thereby accumulating ROS and eventually triggering ferroptotic cell death (Asano et al., 2011

doi: 10.3390/antiox5030027 448 SinghAPSinghRKKimKKSatyanKSNussbaumRTorresMet al

Tintore, M., Vidal-Jordana, A

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Mca is the major detoxification enzyme for MSH S -conjugates with antibiotics, including cerulenin and rifamycin in Mycobacteria (Newton et al., 2008, 2011)