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This beneficial effect was attributed to a plethora of mechanisms, including (i) improved enzymatic antioxidant system capacity with a concomitant decline in the level of lipid peroxidation, (ii) increase in activity of glutathione S-transferase, (iii) downregulation of glucose transporter 1 (GLUT1) restoring normal declined blood glucose levels in tumor cells, (iv) inhibition of lactate dehydrogenase dependent glycolytic machinery, (v) vasodilation of blood vessels resulting in decreased tumor hypoxia and downregulation of the angiogenesis markers

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doi: 10.1523/jneurosci.22-24-10662.2002 63 TangHYJiangAJMaJLWangFJShenGM

5.3.4 Ferroptosis induction Dihydroartemisinin inhibits the downregulation of the expression of the ferroptosis-related proteins GPX4 and FTH in gefitinib-resistant A549 cells, thereby contributing to free iron release (Lai et al., 2023)

Circulating ASP levels increase in people with obesity, insulin resistance or Type 2 Diabetes Mellitus (T2DM), and metabolic syndrome, which increases monocyte chemoattractant protein-1 (MCP-1) and keratinocyte-derived chemokine (KC or IL-8) from their adipocytes through C5L2 or C5aR2 interaction without impacting IL-6 and adiponectin production (243, 244)

Franken DG, Boers GHJ, Blom HJ, and Trijbels JMF (1994)