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The main study groups are summarized in Table 1, and donor demographics are detailed in the electronic supplementary material (ESM Table 1)

The "U-100" designation means the syringe is calibrated so that 100 units equals exactly 1 mL

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Animals received humane care in accordance with Guide for the Care and Use of Laboratory Animals (Eighth Edition) published by National Institutes of Health

Nevertheless, the included studies did not report the potential confounders such as genetic, environmental risk factors, nutrient deficiency or food and drug interactions

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