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Estrogen withdrawal generates a drastic change in the gut microbiome composition, in turn leading to the dysregulation of microbial synthesis and secretion of important neurotransmitters, such as 5-HT and gamma-aminobutyric acid (GABA) (298, 299)

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Animal models help to understand the complex interplay between the different cell types of the CNS and uncover general mechanisms of damage and repair of myelin sheaths

We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo

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For best results, use the serum twice daily, once in the morning and once at night