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Therapeutic response was defined as either normalization of serum alkaline phosphatase (SAP) or a reduction of at least 75% from baseline in total SAP excess at the end of 6 months

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A more honest reading shows promising signals in some areas and significant gaps in knee-specific outcomes

MTHFR (Mthyl-Ttrahydrofolate Rductase) : il sagit dune enzyme implique dans le mtabolisme des folates