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Vitamin B12 Replacement Conclusion B12 deficiency is under appreciated and underdiagnosed

Removal or destruction of the stomach: Vitamin B 12 deficiency can develop in people who have had surgery to remove part or all of the stomach

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However, some observational studies have reported no such correlation, and randomized controlled trials have shown no improvement in cognitive function among older adults with or without dementia, mild cognitive impairment, or Alzheimers disease when supplemented with vitamin B12 alone or in combination with folic acid, vitamin B6, or both

These molecules feed directly into the mitochondrial electron transport chain, which generates adenosine triphosphate (ATP) the primary energy currency of the cell