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The primary difference between the two forms is the molecule attached to the cobalamin (B12) molecule

Zhu AK, Shan YQ, Zhang J, Liu XC, Ying RC, Kong WC (2021) Exosomal NNMT from peritoneum lavage fluid promotes peritoneal metastasis in gastric cancer

Well, dont fall for the hype that theyll magically help you shed pounds or give you Tasmanian Devil-like energy levels

Schmid C, Bianda T, Zwimpfer C, Zapf J, Wiesli P

Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

That's why individuals seeking a well-rounded approach to their vitamin supplements may be interested in a B-Complex, which provides a range of B Vitamins for energy metabolism support