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Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients

doi: 10.1523/JNEUROSCI.3305-11.2011 80 GhatakS.DolatabadiN.TrudlerD.ZhangX.WuY.MohataM.et al

Alternating phases allows pathways to reset and may help maintain effectiveness over time

And I just find long Covid

simultaneous insulin resistance and sugar cravings create a cycle of high-carbohydrate intake that sustains both the yeast and the metabolic dysfunction