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Such effects indicate the need for refined risk assessment methods capable of detecting the consequences of disrupted endocrine functions and hormonal integrity (Vandenberg et al

118 In respiratory tract biopsies from COPD patients, activated NF-B levels were significantly higher than that of normal people, while the level of IB in the lung tissue from smokers or COPD patients was significantly lower than that of non-smoking healthy individuals

Instead, recent studies suggest a key role for nonaxonal mechanisms that include physiological deficits in RGC activity (55, 83) and inflammatory signaling (35, 81)