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Science 291 (5504), 643646

Overexpression of CBS was found to inhibit phosphodiesterase 4A (PDE4A) and phosphodiesterase 8A (PDE8A) via persulfidation, implicating that it is possible that by inhibiting PDE expression via persulfidation and activating the cAMP/PKA pathway that regulates testosterone synthesis, which could be restored ( Figure 5 )

doi: 10.1038/89937

Trends Biochem Sci 32:4450