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siGAPDH) = 0.9552)

Vitamin B12 and other nutrients can affect chemotherapy, making it less effective or more toxic

Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)

In terms of the former this occurs through inhibition of the ubiquinone binding site (atpenin A5, TTFA) or the succinate binding site (malonate) and the latter via autooxidation of flavin (Zhang et al., 1998)

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