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Due to the different pharmacodynamic mechanism of PDE5Is and alprostadil, a synergistic action is conceivable when they are administered in combination

Note that this pathway bypasses the phosphoglycerate kinase reaction, so that the overall yield of ATP per mole of glucose is decreased to zero

J Appl Biology Biotechnol 5(1):047052 Bharti N, Barnawal D (2019) Amelioration of salinity S stress by PGPR: ACC deaminase and ROS scavenging enzymes activity

Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N

Tsang CK, Liu Y, Thomas J et al (2014) Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

While IKK was not the main focus of this study, the identification of a hydroxylation signal on IKK by PHD1 using this non-biased approach adds further evidence in support of IKK being a target of functional hydroxylation