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Abstract Acetaminophen (APAP)-induced acute liver injury (AILI) is primarily driven by CYP3A4mediated overproduction of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), CYP3A4 activity serves as the rate-limiting determinant of NAPQI accumulation levels

doi: 10.1002/cbf.1025 [DOI] [PubMed] [Google Scholar] 16.Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, et al

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